Terminal airway section stained with ethidium homodimer-1 to label permeable cells.
Nanomaterials and Nanotoxicology of the Respiratory System. The goal of this program is to systematically explore the influence of physicochemical properties of engineered nanomaterials (ENMs) on respiratory health and toxicity. This includes the study of inhaled single walled carbon nanotubes, multiwalled carbon nanotubes and nanoparticles in rodent model systems. Mechanisms of acute toxicity, persistence, clearance and correlation of dose with effect are areas of special interest.
Pulmonary Effects of Environmental Oxidant Pollutants: Postnatal Development of Airway Neural Control This project iis designed to examine how neural and non-neural components within the EMTU of the conducting airways contribute to a reactive airway phenotype in infant monkeys. There is a particular emphasis on cells that produce neuropeptides including epithelial cells and macrophages.
Naphthalene Metabolism and Toxicopathology: The naphthalene injury and repair model is used to study wound healing in the deep lung in both adult and neonatal mice. One of the goals of this project are to define the underlying biochemical and metabolic processes responsible for lung injury and to define how Clara cell injury disrupts postnatal development using mouse models of Clara cell injury. An area of interest is the role of hormones on expression of metabolic activation and detoxification systems involved in naphthalene metabolism in the lung of adult male and female mice. We also study kinetics of metabolism of naphthalene in the nose and the lung and study biomarkers of exposure to naphthalene in rodents and humans using urine samples.
Effects of fetal bisphenol a exposure on lung: The goal of this research is to define the effect of prenatal BPA exposure on lung development, particularly of airway secretory cells (Clara cells and Mucous goblet cells).
Health Effects of Central Valley Particulate matter (PM2.5): The major goals are to collaboratively evaluate the differences between PM collected in Davis and Sacramento (summer and winter) in an intra-tracheal mouse model system. Additional studies are underway to define the pulmonary metabolic and immune response in the neonatal rat lung following single and repeated exposures to different formulations of synthesized particles. Particles with and without PAHs including naphthalenes are a particular focus.
Environmental Tobacco Smoke ETS postnatal exposure in mice and the effect of these exposures on the expression of xenobiotic metabolizing enzyme systems throughout the tracheobronchial tree is an area of emphsis. In addition we are studying the effect of ETS exposures on wound healing in the deep lung.
Last updated: Tuesday November 15, 2011
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